Reelin Protien

2024-08-03T07:49:35+00:00

• PAISA - The E280A mutation is by far the most common cause of familial early onset Alzheimer’s disease, affecting hundreds of people. - https://www.alzforum.org/mutations/:~:text=The%20E280A%20mutation%20is%20by,the%20Colombian%20state%20of%20Antioquia. ( Colombian region )
• https://www.npr.org/sections/shots-health-news/2024/07/29/g-s1-13519/alzheimers-protein-reelin-brain-aging-amyloid-tau-memory
  • After he died at 74, an autopsy revealed that the man’s brain was
    • riddled with sticky amyloid plaques, a hallmark of Alzheimer’s.
    • tangled fibers called tau, which can impair neurons.
    • entorhinal cortex - region where Alzheimer's is found
    • He carried a rare variant of the gene that makes the protein Reelin.
      • a variant of the RELN gene that seemed to make the protein more potent.